Area code 646 is an overlay for Manhattan, New York City, alongside area codes 212 and 332. Introduced in 1999, it serves one of the most iconic and densely populated urban areas in the world. Home to Wall Street, Central Park, and countless global brands, 646 is widely used by mobile and business lines. Ten-digit dialing is required. Though newer than 212, 646 has become strongly associated with the digital age and urban lifestyle in the heart of NYC.